Drug

Dose

Special precautions

Zidovudine, ZDV, AZT
Retrovir pediatric suspension, 50mg/5ml (A)

Dose for prophylaxis (full term new born): 2mg/kg orally every six hours starting within 12 hours of birth and continuing for 6 weeks.
Treatment - 180Mg/M2 every six hours (total 720mg.m2/day). Maximum dose should not exceed 600mg/day

Strawberry flavoured syrup.
Store at 15-250°c.

Stavudine, d4T
Zerit pediatric 1 mg/ml (A)

1 mg/kg every 12 hours for patients less than 30kg:
30mg twice daily for patients between 30-59kg:
40mg twice daily for patients over 60kg.

Oral solution (made from powder) should be refrigerated (2-80°c) after reconstitution. shake well before use.
Discard 30 days after reconstitution.

ddl, pediatric
Videx powder.
10mg/ml(NA)

120mg/m² every 12 hours

This is an oral solution made from
Shake well before use and keep refrigerated (2080c). The solution is stable for 30 days.
Take > 30 minutes before or 2 hours after eating.

Lamivudine, 3TC
Epivir solution

4mg/kg twice daily for children aged 3 months to 16 years.

The oral solution can be stored between
The oral solution can be stored between 2-30°c. Can be taken with or without food.

10mg/ml(A)

Daily maximum dose is 300mg/day.

Abacavir, Ziagen
20mg/ml (NA)

8mg/kg twice a day for children aged > months to 16 years.
Maximum dose is 600mg/day.

Store at 20-250°c. Can be taken with or without food.

Efavirenz, Stocrin 50, 100, 200mg capsules. (A)

20mg once a day (10 to < 15kg)

Indicated for children aged 3 years and above, weighing > 10kg and who can swallow hard capsules.

250mg once a day (15 to <20kg)

300mg once a day (20 to <25kg)

350mg once a day (25 to 32.5kg)

400mg once a day (32.5 to >40kg)

600mg once a day (>40kg)

Nevirapine, Viramune pediatric 10mg/ml.

4mg/kg once a day for 14 days.

Oral solution should be stored between 2 and 30°c. Can be taken with or without food.

Thereafter, maintenance dose:

Children > 2 months to <8 years:

7mg/kg twice a day.

Children > 8 years: 4mg/kg twice a day.

Maximum recommended dose: 400mg/day.

Drug

Dose

Special Precautions

Nelfinavir, Pediatric Viracept powder, 50mg per 19 scoop. (A)

30-30mg/kg three times daily for children aged 2-13 years.

The oral solution is made from the powder is Stable for upto 6 hours after reconstitution. The powder may be reconstituted with water, milk formula, soy formula, soy milk or dietary supplements. It has a bitter taste I reconstituted with acidic food/juice. It can be taken with a meal or light snack and should be taken 1 hour after or more than 2 hours before ddl.

Ritonavir, Pediatric Norvir syrup 80mg/ml

Initial dose 250Mg/M2 every 1 2 hours, increased by 50mg/m² at 2-3 day intervals to 400mg/m² twice daily (recommended dose). If 400mg/m² is not tolerated, the highest tolerated dose should be used. Maximum dose: 600mg twice daily.

The oral solution should not be refrigerated but stored at 20-25°C. Shake well before use.

Amprenavir, Agenerase, 50, 100mg capsules
Oral solution: 15mg/ml.
NB: Capsules and oral solution are not interchangeable on a milligram per milligram basis. (NA)

Efficacy and safety of Amprenavir have not been established in patients younger than 4 years of age.
Oral capsules: for patients between 4-12 years of age or for patients 13 to 16 years of age who weigh less than 50kg, the recommended dose is 20mg/kg twice daily or 15mg/kg three times daily. The maximum daily dose is 2400mg. For adolescents 13-16 years of age who weigh 50kg or more the recommended dose is 1200mg twice daily. Oral solution: for patients between 4-12 years of age or for patients 13 to 16 years of age who weigh less than 50kg, the recommended dose or oral solution is 22mg/kg twice daily or 17mg three times daily. The maximum daily dose of Amprenavir oral solution is 2800mg.

Amprenavir may be taken with or without food, but should not be taken with a high fat meal. Amprenavir oral solution and capsules should be stored at room temperature and neither solution nor the capsules should be refrigerated. Amprenavir capsules and oral solution are NOT bioequivalent, and thus are not interchangeable on a milligram per milligram basis.