Standard regimen:

Streptomycin: give 1 g (IM)
every 24 hours for 8 weeks (for those weighing 50 kg or more and aged 40 years or less)

OR

give 750 mg every 24 hours for 8 weeks for those weighing less than 50 kg and aged 40 years or less.

Children:

Streptomycin: give 15 mg/kg body weight IM every 24 hours for 8 weeks.

NOTE

• If Ethambutol is to be given for more than 8 weeks reduce to 15 mg/kg body weight.
• Ethambutol should not be given to children.

Pre-treatment weight

Number of (Thiazina tablets of 100 mg Isoniazid and 50 mg Thiacetazone) in one dose only

Number of (Thiazina tablets of 300 mg Isoniazid and 150 mg Thiacetazone) in one dose daily

Streptomycin (g) in one dose daily

< 10 kg

1/2

1/2

0.25

11-20 kg

1

1

0.50

21-30 kg

2

1

0.75

31-50 kg

3

1

0.75

> 51 kg

3

1

1.00

Daily during week 1-8

Daily during weeks 9-32

S

HR

z

TH

Pre-treatment weight

Streptomycin intramuscular injection

Isoniazid 100 mg Rifampicin 150 mg (combined tablets)

Pyrazinamide 0.5 tablets

Isoniazid 300 mg and Thiacetazone 150 mg OR Isoniazid 100 mg and Thiacetazone 150 mg

> 50 kg

1 gm

4

4

1 or 3

31-49 kg

0.75 gm

3

3

1 or 3

<30 kg

0.75 gm

2

2

1 or 2

NOTE • Streptomycin will be replaced by Ethambutol step wise in the country (starting 1992). In case of side effects with Thiazina, Ethambutol plus Isoniazid must be used.