Neostigmine

Tablet (Bromide), 15 mg
Injection (Methylsulphate), 0.5 mg/ml, 2.5 mg/ml in 1 ml ampoules

Indications: - in the treatment of conditions such as myasthenia gravis and to reverse muscle relaxation produced by competitive (non-depolarizing) muscle relaxant

Cautions, Contraindications, Drug interactions, Side effects, see section 5.3 under neostigmine.

Dose and Administrations

By mouth, neostigmine bromide 15 - 30 mg at suitable intervals throughout day, total daily dose 75 - 300 mg; Neonate 1 - 5 mg every 4 hours, half an hour before feeds; Child up to 6 years initially 7.5 mg, 6-12 years initially 15 mg, usual total daily dose 15 - 90 mg.

By subcutaneous or intramuscular injection - neostigmine methylsulphate 1 - 2.5 mg at suitable intervals throughout day (usual total daily dose 5 - 20 mg); Neonate 50 - 250 micrograms every 4 hours half an hour before feeds; Child 200 - 500 micrograms as required.