Non-ulcer dyspepsia is a chronic, recurrent, often meal-related epigastric discomfort, pain or fullness. The location of the pain and the relationship to meals resembles the classic description of PUD except that no evidence for ulcer will be found by either endoscopy or barium studies.

Diagnosis is often made on clinical grounds but endoscopy or barium meal studies might be required to exclude ulcer.

Treatment

First line:

Mixtures of Aluminium hydroxide and Magnesium trisilicate, 10 - 30 ml or

2 - 4 chewable tablets p.o. taken between meals prn.

S/E: rare and mild

C/I: insignificant

Dosage forms: suspension, 310 mg + 620 mg in 5 ml; tablet (chewable), 120 mg + 250 mg; 250 mg + 500 mg.

OR

Mixtures of Magnesium hydroxide and aluminium hydroxide, 10 - 30 ml or 2 - 4 chewable tablets, p.o. between meals prn.

Dosage forms: chewable tablet, 400mg + 400 mg, 195mg + 220mg in 5 ml.

OR

Magnesium trisilicate 2 - 4 chewable tablets, p.o. between meals prn.

Dosage forms: chewable tablet, 500 mg.

OR

Magnesium hydroxide, 10 - 30 ml or 2 - 4 chewable tablets, p.o. between meals PRN.

Dosage forms: chewable tablet, 300mg + 311mg; Mixture, 375mg/5ml, 7.75%.