Oral thrush is commonly seen in neonates especially pre-terms whose immune system is immature. In addition the condition occurs commonly in infants. However, with HIV infection and immunosuppression, the condition is persistent or recurrent and may lead to growth failure as a result of poor feeding. Oral thrush may extend into the oesophagus leading to pain on swallowing.
Oral candidiasis should be treated with Nystatin oral suspension, 100,000 units 6 hourly for 2 weeks
Give Ketoconazole, 3-6mg/kg/day for 7 days if there is oesophageal candidiasis. Alternatively, IV Ampotericin B 0.5mg/kg/day for 10-14 days can be given if ketoconazole is contraindicated or ineffective such as in active liver disease, risk of disseminated candidiaisis, lack of response to oral therapy and inability to tolerate oral medication