PGL is a common clinical manifestation of HIV infection in infants and children. The distribution of enlarged lymph nodes in children is similar to that found in adults. The investigation and management of children presenting with generalised lymphadenopathy is the same as that for adults. In children lymphadenopathy is defined as lymph node swelling in two or more anatomical sites (neck, armpit or groin). The major difference is that children commonly develop PGL as a result of bacterial skin infections and systemic viral infections commonly encountered in childhood. Hence conditions that cause generalised dermatitis, e.g., eczema, infected scabies and the viral infections such as infectious mononucleosis, cytomegalovirus infections, should always be kept in mind. Other causes of PGL in children are tuberculosis, leukaemia and lymphoma.