The use of single drugs in the treatment of HIV infection is not recommended. Antiretroviral therapy both in naïve patients and those who had received treatment before, involves the use of combinations of drugs. A triple therapy consisting of 2 NRTI + 1 NNRTI or 2 NRTI + 1 P1 is recommended. There is no single combination that is best for every patient and that can be tolerated by all. Regimens should be recommended for patients based on their clinical condition, lifestyle, and ability to tolerate the regimen. Below are the recommended first line drugs combinations in Tanzania.