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close this bookNational Guidelines for the Clinical Management of HIV/AIDS - Tanzania (NACP; 2005; 131 pages)
View the documentLIST OF ABBREVIATIONS
View the documentACKNOWLEDGEMENTS
View the documentFOREWORD
Open this folder and view contentsCHAPTER 1: INTRODUCTION
Open this folder and view contentsCHAPTER 2: ORGANIZATION OF HIV/AIDS CARE AND TREATMENT
Open this folder and view contentsCHAPTER 3: HIV/AIDS PREVENTION
Open this folder and view contentsCHAPTER 4: PROTECTIVE MEASURES AGAINST HIV TRANSMISSION
close this folderCHAPTER 5: LABORATORY TESTS IN HIV/AIDS
Open this folder and view contents5.1 Tests for HIV Diagnosis
View the document5.2 Tests for treatment eligibility and efficacy monitoring
close this folder5.3 Tests for treatment safety monitoring
View the document5.3.1 Grading of adverse reactions in adults and adolescents
View the document5.4 Laboratory Safety Procedures
View the document5.5 Phlebotomy Safety Procedures
View the document5.6 Sample Storage Procedures
View the document5.7 Sample Transportation Procedure
Open this folder and view contentsCHAPTER 6: HIV/AIDS AND PREGNANCY
Open this folder and view contentsCHAPTER 7: PEDIATRIC HIV/AIDS AND RELATED CONDITIONS
Open this folder and view contentsCHAPTER 8: COMMUNITY AND HOME BASED CARE FOR PEOPLE LIVING WITH HIV/AIDS (PLHA)
Open this folder and view contentsCHAPTER 9: COUNSELLING RELATED TO HIV-TESTING AND TREATMENT ADHERENCE
Open this folder and view contentsCHAPTER 10: MANAGEMENT OF COMMON SYMPTOMS AND OPPORTUNISTIC INFECTIONS IN HIV/AIDS
Open this folder and view contentsCHAPTER 11: MANAGEMENT OF MENTAL HEALTH PROBLEMS IN HIV/AIDS
Open this folder and view contentsCHAPTER 12: MANAGEMENT OF HIV INFECTED PATIENTS USING ANTIRETROVIRAL DRUGS
Open this folder and view contentsCHAPTER 13: ARV THERAPY IN INFANTS AND CHILDREN
Open this folder and view contentsCHAPTER 14: USE OF ARVS IN SPECIAL CIRCUMSTANCES
Open this folder and view contentsCHAPTER 15: HIV/AIDS AND NUTRITION
Open this folder and view contentsCHAPTER 16: MANAGEMENT OF ANTIRETROVIRAL MEDICINES
Open this folder and view contentsCHAPTER 17: CERTIFICATION OF HEALTHCARE FACILITIES AS CARE AND TREATMENT SITES
 

5.3.1 Grading of adverse reactions in adults and adolescents

Table 5: Laboratory Adverse Events in Adults (ACTG)

LABORATORY TEST ABNORMALITIES

ITEM

GRADE 1 TOXICITY

GRADE 2 TOXICITY

GRADE 3 TOXICITY

GRADE 4 TOXICITY

Haemoglobin

8.0-9.4 g/dL

7.0-7.9 g/dL

6.5-6.9 g/dL

<6.5 g/dL

Absolute Neutrophil Count

1-1.5 x 109/L

0.75-0.99 x 109/L

0.5-0.749 x 109/L

<0.5 x 109/L

ALT

1.25-2.5
upper normal limit

>2.5-5
upper normal limit

>5.0-10
upper normal limit

>10
upper normal limit

Triglycerides

3-4.51 mmol/L

4.52-8.48 mmol/L

8.49-13.56 mmol/L

>13.56 mmol/L

Cholesterol

>1.0-1.3
upper normal limit

>1.3-1.6
upper normal limit

>1.6-2.0
upper normal limit

>2.0
upper normal limit

MANAGEMENT

Continue ART
Repeat test 2 weeks after the initial test and re-assess

 

Continue ART
Repeat test 1 week after initial test and reassess; if ALT still grade 3 consult expert about stopping ART

Consult expert immediately before stopping ART

Note: the repeat tests may require additional patient’s visits over and above the routine monitoring visits


Table 6: Grading the severity of adverse reactions in children

LABORATORY TEST ABNORMALITIES

ITEM

GRADE 1 TOXICITY

GRADE 2 TOXICITY

GRADE 3 TOXICITY

GRADE 4 TOXICITY

Haemoglobin
> 3 mo. - < 2 y. o.

9.0-9.9 g/dL

7.0-8.9 g/dL

<7.0 g/dL

Cardiac failure secondary to anaemia

Haemoglobin
≥2 y.o.

10-10.9 g/dL

7.0-9.9 g/dL

<7.0 g/dL

Cardiac failure secondary to anaemia

Absolute Neutrophil Count

0.75-1.2 x 109/L

0.4-0.749 x 109/L

0.25-0.399 x 109/L

<0.25 x 109/L

ALT (SGPT)

1.1-4.9 µg/l
upper normal limit

5.0-9.9 µg/l
upper normal limit

10.0-15.0µ/l
upper normal limit

>15 µg/l
upper normal limit

Triglycerides

-

1.54-8.46 mmol/L

8.47-13.55 mmol/L

>13.56 mmol//L

Cholesterol

-

4.43-12.92 mmol/L

12.93-19.4 mmol/L

>19.4 mmol/L

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