STUDY |
DRUG |
ANTEPARTUM |
INTRAPARTUM |
POSTPARTUM |
INFANT |
REDUCTION IN MTCT |
PACTOG 076
Non Breast feeding |
AZT |
100 mg p.o. 5 times daily starting at 14-34 week gestation. |
1v 2mg/kg loading, then 1 mg/kg/hr |
No |
2mg/kg p.o. 6 hourly for 6 weeks |
68% (infection status at 18 months |
Thailand
Non breast feeding |
AZT |
300 mg p.o. bd, p.o starting at 36 weeks gestation |
300mg p.o 3hrly |
No |
No |
50% (infection status at 6 months age) |
Cote D voire
Breast feeding |
AZT |
300 mg p.o. Bd, p.o. starting at 36 weeks gestation |
300mg p.o 3hrly |
No |
No |
47% (infection status at 6 weeks age) |
Cote D voire
Burkina Faso
breast feeding |
AZT |
300 mg p.o. bd, starting at 36 weeks gestation |
600mg p.o at the onset of labour |
300mg bd for 1 week |
No |
38% (infection status at 6 months age) |
Africa-Petra
Arm A 67%
Breast feeding |
AZT +3TC |
300mg AZT + 150mg +3TC . starting at 36 weeks gestation |
300mg AZT+ 150mg 3TC p.o 3 hourly |
300mg AZT + 150mg 3TC p.o bd for 1 week |
AZT 4mg/kg + 3TC 2mg/ kg p.o bd for 1 week |
38% (infection status at 6 months age) |
Africa-Petra
Arm B 67%
Breast feeding |
AZT 300mg +3TC 150mg (combivir) |
No |
300mg AZT+ 150mg 3TC p.o 3 hourly |
300mg AZT + 150mg 3TC p.o bd for 1 week |
AZT 4mg/kg + 3TC 2mg/ kg p.o bd for 1 week |
37% (infection status at 6 weeks age) |
VIVNET
Breast feeding |
|
No |
200mg single dose at the onset of labor |
No |
2mg/kg single dose in the first 72 hours |
47% (infection status at 6 weeks) |
