Clinical features: These acute systemic diseases result from infection by Salmonella typhi and S. paratyphi. A an B respectively. The clinical manifestations and duration of illness vary markedly from one patient to another. The major clinical features are fever, severe headache, drowsiness and aching in the limbs. The course of paratyphoid tend be to shorter and less severe compared to typhoid.
Treatment guidelines |
Chloramphenicol (O) |
Adult |
500 mg every 6 hours for 14 days. |
Children above 1 year |
12.5 mg/kg body weight six hourly for 14 days. |
Children below 1 year |
25/30 mg/kg body weight six hourly for 14 days |
Alternatives |
Co-trimoxazole (O) |
Adult |
960 mg 12 hourly for 14 days. |
Children above six weeks |
120 mg/kg body weight every 12 hours for 14 days |
| |
Or |
| |
Amoxycillin (O) |
Adult |
1 g every 8 hours for 14 days. |
Children |
25 mg/kg body weight every 8 hours for 14 days. |
NOTE: Co-trimoxazole and Amoxycillin are first choice drugs for paratyphoid. |
